Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional. Pittella JE, de Castro LP. Wernicke’s encephalopathy manifested as Korsakoff’s syndrome in a patient with promyelocytic leukemia. South Med. Wernicke encephalopathy (WE) is an acute neurological condition characterized by a clinical Diekfuss JA, De Larwelle J, McFadden SH.

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Review [Wernicke encephalopathy and Korsakoff’s psychosis: American Journal of Psychiatry.

Sequeira Lopes da Silva 1R. The location of the lesions were more frequently atypical among non-alcoholics, while typical contrast enhancement in the thalamus and the mammillary bodies was observed frequently associated with alcohol abuse. Cecil Medicine, chapter23rd ed. Thiamine can be measured using an erythrocyte transketolase activity assay, [5] or by activation by measurement of in vitro thiamine diphosphate levels. Clear Turn Off Turn On.

[Wernicke’s encephalopathy and Caine criteria. Report of six cases].

Wernicke’s encephalopathy in crack-cocaine addiction. In the last stage others symptoms may occur: Riboflavin deficiency B 3: Oxf Med Case Reports.

Since the cornerstone of therapy is thiamine, the importance of compliance is vital. Sarayu Vasan ; Anil Kumar. Lancet Neurol ; 6: However, survivors of WE may develop korsakoff psychosis and require long-term encefalopattia. Wernicke’s encephalopathy induced by total parental nutrition.


StatPearls Publishing ; Jan. The classical triad is enncefalopatia confusional state, ocular abnormalities and ataxia. Due to its high morbi-mortality, diagnosis and treatment should be made as soon as possible.

European Journal of Neurology. WE is a serious medical disorder which carries an enormous morbidity and mortality. Olgado Ferrero 1M.

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An Orphanet summary for this disease is currently under development. However, a complete blood count and the comprehensive metabolic panel can be completed to exclude other causes of central nervous system abnormalities.

Specifically, it acts as an essential coenzyme to the TCA cycle and the pentose phosphate shunt. A case associated with a liquid-only diet. Health care resources for this disease Expert centres 0 Encefaloaptia tests 0 Patient organisations 0 Orphan drug s 0.

Vitamin E deficiency K: WE was first identified in by the German neurologist Carl Wernickealthough the link with thiamine was not identified until the s. A year-old man without any relevant medical history was admitted in our Intensive Care Unit with the diagnosis of hemorrhagic shock due to a bleeding ulcer in the first duodenal curve.

[Wernicke’s encephalopathy and Caine criteria. Report of six cases].

An altered blood—brain barrier may cause a perturbed response to certain drugs and foods. Malnutrition or nutrition disorders E40—E68— The presence of only one sign should be sufficient for treatment.


Antibiotics were prescribed due to Escherichia coli peritonitis. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Wernicke encephalopathy and beriberi during total parenteral nutrition attributable to multivitamin infusion shortage. Thiamine, also called B1, helps to break down glucose.

Orphanet: Encefalopatia de Wernicke

The prevalence of this encephalopathy in men is higher than in women 1,7: From Wikipedia, the free encyclopedia. Other specialists may be required according to organ involvement. Handbook of Clinical Neurology.

Only one-third of patients will have all three of the typical symptoms, being the confusional state the most frequent one, followed by ataxia and ocular dysfunction. Therefore, deficiency of thiamine will lead to decreased levels of alpha-keto-glutarate, acetate, citrate, acetylcholine and accumulation of lactate and pyruvate. Pellagra Niacin deficiency B 6: As a much more diverse range of symptoms has been found frequently in patients it is necessary to search for new diagnostic criteria, however Wernicke encephalopathy remains a clinically-diagnosed condition.

Pyridoxine deficiency B 7: