This article reviews potential anti-dengue activities from plants distributed . In the Philippines, Euphorbia hirta, known locally as “tawa–tawa”. Management of thrombocytopenia and flu-like symptoms in dengue patients with herbal water of Euphorbia hirta. Mir M, Khurshid R, Aftab R. BACKGROUND. PDF | Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue.

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About dosage preparations were administered internally by mouth while the rest were applied topically to affected areas. A water decoction of guava leaves contains quercetin, which acts to inhibit the formation of enzyme mRNA in the virus [ 56 ].

De Guzman et al documented the use of E hirta for dengue among three indigenous groups in Pangasinan: Since there is no specific cure against dengue, treatment modalities include supportive measures to address specific symptoms. The global incidence of dengue has grown dramatically in recent decades, particularly in urban areas in countries with tropical climates, and becoming a leading cause of death among children [ hirtaa ].

Several ethnomedicinal studies have also reported that leaves are the most frequently used part because of their remarkable identity and accessibility in addition to the fact that most biosynthesis of therapeutically active constituents occur in leaves [ 10 – 12 ].

The number of use reports pertaining to symptoms of dengue and other diseases were tallied from 82 informants living in Anda Island, Mt. Solomon T, Mallewa M. It is a species of oak native to Morocco, Portugal and Spain.


The locals who speak mostly Ilocano depend on fruit crops, farming, and logging; and. Similarly, the bleeding time hirts was increased by the i.

Antiviral activity of some Nigerian medicinal plants extracts. No appointments were made prior to these visits.

Potential anti-dengue medicinal plants: a review

In addition, mosquito control programs are the most important preventive method [ 6 ]. The water decoction of leaves from Euphorbia hirtalocally known as gatas—gatas, is used in the Philippines as a folk euhporbia to treat DF [ 54 ]. It is a common weed in garden beds, garden paths and wastelands and is found throughout Java, Sunda, Sumatra, Peninsular Malaysia, the Philippines and Vietnam. Dengue possesses a wide clinical manifestation ranging from nonsevere to severe forms [ 5 ].

Table 1 Tally of use reports of E.

Table 6 Dosage preparation of Euphorbia hirta compounded according to plant part. Despite its lethal consequences, the staggering numbers of those affected are increased by the fact that, at present, there is no specific antiviral treatment or vaccine for DF [ 3 ].

Journal of Tropical Medicine

In addition, we describe species used as euphirbia treatment for dengue together with their isolated compound. The inhibitory actions of Houttuynia cordata aqueous extract on Dengue virus and Dengue-infected cells. In Malaysia, with a population of Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue. Indexed in Web of Science.


The lack of specific treatment and the potentially severe consequences fuels the search for alternative therapies. Psidium guajava Psidium guajava belongs to family Myrtaceae.

Overview of studies on plant species used as anti-dengue The use of herbal-based medicine and medicinal plants to treat many diseases is growing worldwide as they has few or no adverse effects.

Euphorbia hirta – a possible cure for dengue

Dengue fever, Anti-dengue, Medicinal plants, Phytochemical. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The methanolic extract of A. Quercus lusitanica belongs to family Fagaceae. Flagellaria indica was investigated for its anti-dengue properties in Vero cells [ 2 ]. Chowdhury MS, Koike M. Acta Biochim Biophys Sin.

Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence

The symptoms of dengue range from a mild flu-like syndrome known as dengue fever [DF] to the most severe forms of the disease, which are characterized by coagulopathy, increased vascular permeability, and plasma leakage dengue hemorrhagic fever [DHF] which eventually leads to dengue shock syndrome DS [ 5 ].

Leucaena leucocephala Leucaena leucocephala belongs to family Fabaceae. The available eiphorbia conclusively demonstrates the potential of E.